S6059 A Rare Case of Giant Duodenal Polyp

Introduction: Brunner’s gland adenomas (BGAs) are rare benign duodenal tumors arising from submucosal Brunner’s glands, which secrete alkaline mucus for mucosal protection. Most BGAs are small and asymptomatic, but larger lesions (>2 cm) may cause gastrointestinal bleeding or anemia. We report a case of a giant BGA presenting with melena and severe iron deficiency anemia, managed successfully with endoscopic resection. Case Description/Methods: A 52-year-old man with hyperlipidemia presented with exertional dyspnea and melena for 1 month. He denied nonsteroidal anti-inflammatory drug or anticoagulant use. Labs showed microcytic anemia (hemoglobin 5.3 g/dL, ferritin 4 ng/mL, transferrin saturation 6.5%). After receiving 3 units of packed red blood cells and intravenous pantoprazole, hemoglobin rose to 8.0 g/dL. Esophagogastroduodenoscopy revealed mild gastric erosions and a large, 5 cm pedunculated polyp in the second portion of the duodenum. Patient underwent subsequent endoscopy for polyp removal, where 3 mL of epinephrine (1:10,000) was injected into the polyp base. Hemostasis was secured with 4 hemoclips, followed by snare cautery polypectomy. Due to the polyp’s large size, retrieval through the pylorus required use of a 4-wire stone extraction basket. Further resistance at the upper esophageal sphincter necessitated overtube-assisted extraction. Histopathology confirmed Brunner’s gland adenoma with lobulated nests of bland Brunner’s glands separated by fibrous septa. Gastric biopsies were positive for Helicobacter pylori and treated with concomitant therapy. At follow-up, the patient reported full resolution of symptoms, and hemoglobin improved to 11.1 g/dL. Discussion: This case illustrates that large BGAs can cause occult GI bleeding and iron deficiency anemia. Due to their submucosal origin, superficial biopsies may be non-diagnostic, requiring complete resection for definitive diagnosis. Endoscopic management is a safe, minimally invasive alternative to surgery, even for large lesions, when appropriate hemostatic techniques and retrieval strategies are used. Though the link between H. pylori and BGAs remains speculative, co-detection may warrant eradication. Long-term outcomes following resection are excellent, with low recurrence and no proven malignant potential.