POTENTIAL OF MESOTHERAPY AND BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB) IN MUSCLE HYPERTROPHY

Introduction: Mesotherapy is a medical technique that administers medications directly to the affected area, using reduced and localized doses to achieve a specific therapeutic effect. Objective: To explore the potential of mesotherapy combined with HMB (beta-hydroxy-beta-methylbutyrate) in promoting muscle hypertrophy. Methodology: This study consists of a review of the scientific literature, covering articles, meta-analyses, and experimental studies on the synthesis, metabolism, efficacy, dosage, and mechanisms of action of HMB. Theoretical Framework: HMB, a metabolite of leucine, is recognized for its anticatabolic effects and is gaining attention for its ability to enhance athletic performance and promote muscle hypertrophy. The role of HMB in preserving and increasing muscle mass underscores its effectiveness in both sports and clinical contexts, particularly in debilitated individuals. However, the efficacy of HMB may vary depending on the context of application, exercise intensity, and the health status of individuals. Conclusion: It is concluded that mesotherapy associated with HMB is a promising approach for promoting muscle hypertrophy, especially under specific conditions. However, its efficacy is influenced by various factors, and future research should focus on controlled clinical studies to determine the optimal conditions for HMB use.