S6466 Successful Treatment of a Chronic Gastric Phytobezoar Using Effervescent Therapy: A Case Report

Introduction: Bezoars are aggregates of indigestible material within the gastrointestinal tract, commonly presenting with nonspecific symptoms such as abdominal pain, nausea, and loss of appetite. Risk factors include previous gastric surgery, diabetes mellitus with gastroparesis, persimmon ingestion, poor mastication, and certain psychiatric conditions. Bezoars can be managed through dissolution, mechanical fragmentation, or endoscopic retrieval. Among dissolution agents, carbonated beverages such as Coca-Cola® have been reported as effective in a few case reports with modes of delivery including nasogastric lavage, oral ingestion over several days, or endoscopic injection. We present a case of a chronic, large bezoar successfully treated with oral Coca-Cola administration. Case Description/Methods: A 64-year-old woman with a history of asthma, hirsutism, hypertension, morbid obesity, hyperlipidemia, cyclothymia, and breast cancer status post partial right mastectomy was under evaluation for weight management and eating disorder. She reported intermittent dysphagia for 1 year warranting gastroenterology consultation. One year prior non-contrast computed tomography (CT) thorax showed high-density material in the stomach, previously presumed to be residual tablets. Follow-up esophagogastroduodenoscopy (EGD) was performed revealing an unremarkable esophagus but a gastric phytobezoar occupying >50% of gastric volume obscuring mucosal visualization and further leading to premature procedure termination. The patient was instructed to ingest 3 liters of carbonated soda over 3-6 hours. Repeat EGD the following day showed complete resolution of the bezoar, with no residual material in the stomach. Discussion: This case highlights the effectiveness of carbonated beverages such as Coca-Cola for the non-invasive management of a large, chronic gastric phytobezoar. While multiple treatment strategies exist, the use of carbonated beverages remains a safe, accessible, and cost-effective option. Dissolution with Coca-Cola is proposed to work through mucolytic effects as well as weak acid (H2CO3/H3PO4) based fiber matrix disruption. This approach may help avoid invasive interventions or aid in endoscopic interventions by making the bezoar malleable to removal. Continued awareness and documentation of such treatment successes are important to guide future management strategies.