Higher diversity and abundance of microRNA-455-5p isoforms confer suppressive role in Wilms’ tumor

This study provides the first comprehensive analysis of isomiRs in WT, identifying miR-455-5p isoform diversity as a novel prognostic indicator. The specific isoform miR-455-5p 0|1 likely exerts a tumour-suppressive role, potentially through a non-canonical regulatory interaction with <i>SP100</i>. These findings unveil isomiR-mediated regulation as a critical layer of molecular complexity in Wilms' tumour, offering new insights for prognostic stratification.