Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation

We proposed an efficient DLP model for predicting allograft rejection, and revealed an unexpected immunological mechanism of TLS in allograft rejection livers and clarified an IFN-γ-JAK-STAT-dependent circuit that could be targeted with drugs and transformed AtM B cells into potent instigators of hepatocellular injury in allograft rejection.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-11
DOI
https://doi.org/10.3389/fimmu.2025.1728290
Primary Topic
T-cell and B-cell Immunology
Type
article
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article

Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation

Frontiers in Immunology
T-cell and B-cell Immunology
article

Tertiary lymphoid structure drives allograft rejection via IFN-γ-JAK-STAT-dependent atypical memory B cell differentiation

article en

Abstract

We proposed an efficient DLP model for predicting allograft rejection, and revealed an unexpected immunological mechanism of TLS in allograft rejection livers and clarified an IFN-γ-JAK-STAT-dependent circuit that could be targeted with drugs and transformed AtM B cells into potent instigators of hepatocellular injury in allograft rejection.

Frontiers in ImmunologyVol. 16
Renji Hospital (CN), Shanghai Institute of Hematology (CN), Shanghai Clinical Research Center (CN)
Openalex Percentile: Top 38%
T-cell and B-cell Immunology
DOIOpen Access PDFOpenAlex
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