S2622 Racial Disparities in Cardiac Outcomes Among Cirrhotic Patients With Acute Pancreatitis

Introduction: Racial disparities in health outcomes are well-documented in both acute pancreatitis (AP) and cirrhosis, yet their combined impact on cardiac complications remains underexplored. Socioeconomic inequities, differential comorbidity burdens, and systemic healthcare barriers contribute to these disparities. This study investigates one-year cardiac outcomes among racial groups in patients with coexisting AP and cirrhosis, providing critical insights into inequities in healthcare and outcomes. Methods: A retrospective cohort study was conducted using the TriNetX database, analyzing 26,160 patients with AP and cirrhosis stratified by self-identified race (Black, White, Hispanic, and Other). Primary outcomes included the incidence of cardiac arrest, heart failure (HF), and arrhythmias. Propensity score matching accounted for demographic and clinical covariates, ensuring balanced comparisons across racial groups. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated to assess disparities. Results: Black patients exhibited disproportionately higher rates of cardiac complications, including cardiac arrest (HR: 2.93; CI: 2.34–3.65; P < 0.001) and HF (HR: 1.67; CI: 1.35–2.07; P < 0.001), compared to White patients. Hispanic patients showed an elevated risk of arrhythmias (HR: 1.22; CI: 1.01–1.48; P = 0.042). These disparities persisted despite adjustments for socioeconomic status and clinical factors, indicating the significant role of structural inequities and potential biological differences. Conclusion: Racial disparities in cardiac outcomes among cirrhotic AP patients highlight systemic inequities in healthcare delivery and biological vulnerabilities in underserved populations. Black and Hispanic patients face disproportionately higher risks of severe complications, underscoring the need for culturally tailored interventions and equitable healthcare policies. Future research should focus on mechanisms driving these disparities and effective strategies to mitigate them.