S2956 Transforming Gastrointestinal Cancer Care Through Artificial Intelligence: Breaking Barriers With Patient-Friendly Education

Introduction: The global burden of gastrointestinal (GI) cancer is significant, accounting for 26% of global cancer incidence and nearly 35% of cancer-related mortality. Effective patient education is crucial in managing GI cancers. Recently, Artificial intelligence (AI) has revolutionized medicine, enhancing diagnostics, personalized care, and research. However, despite the availability of educational content from reputable professional societies, none are tailored to patient literacy levels. We attempted to increase awareness by using AI tools—ChatGPT (OpenAI), Copilot (Microsoft), and Gemini (Google)—to deliver complex information to patients with low health literacy. Methods: A questionnaire for patient education resources on esophageal, gastric, hepatocellular, and pancreatic cancers, sourced from the American College of Gastroenterology website. We utilized various AI tools - ChatGPT, Copilot, and Gemini to simplify to the reading level <6th grade. The responses were analyzed using the Flesch-Kincaid Grade Level (FKGL), Flesch Reading Ease Score (FRES), Reading Level, and average words per sentence. Statistical significance was determined by paired t-test with P value < 0.05. Results: FKGL indicates the U.S. school grade level required to understand a text, while FRES measures readability on a scale from 0 (very difficult) to 100 (very easy). All 3 AI tools have shown significant differences in FKGL and FRES scores in all GI cancers. The difference noted in the average words count is variable across different AI tools and GI cancers. The average Reading Level of the original education material is at the level of Grade 10th grade to college. ChatGPT and Copilot have simplified it to the Grade 8 to 9th grade, whereas Gemini to 6 to 7th grade. Conclusion: AI tools effectively simplify medical information on GI cancers, improving accessibility and comprehensibility for individuals with varying literacy levels. The modifications made by ChatGPT, CoPilot, and Gemini showed statistically significant differences (P < 0.05), indicating successful text simplification. No AI tool demonstrated greater effectiveness, as all were equally effective in simplifying the text. Demonstrated that AI can deliver powerful, audience-tailored insights by turning complexity into clarity.