How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort

For commonly used pain questionnaires, pain severity seems linked with inflammatory activity more than structural damage. Structural damage is primarily associated with nociceptive-like pain according to PainDETECT, which might be valuable for patient selection to clinical trials and observational studies.

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Publication Details

Journal
Osteoarthritis and Cartilage Open
Published
2025-12-11
DOI
https://doi.org/10.1016/j.ocarto.2025.100726
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort

Osteoarthritis and Cartilage Open
Osteoarthritis Treatment and Mechanisms
article

How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort

article en

Abstract

For commonly used pain questionnaires, pain severity seems linked with inflammatory activity more than structural damage. Structural damage is primarily associated with nociceptive-like pain according to PainDETECT, which might be valuable for patient selection to clinical trials and observational studies.

Osteoarthritis and Cartilage OpenVol. 8(1)
Boston University (US), Harvard University (US), Inserm (FR), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Utrecht University (NL), Paracelsus Medical University (AT), Leiden University Medical Center (NL), University Medical Center Utrecht (NL), Sorbonne Université (FR), Massachusetts General Hospital (US), Universitätsklinikum Erlangen (DE), Assistance Publique – Hôpitaux de Paris (FR), Hôpital Saint-Antoine (FR), Diakonhjemmet Hospital (NO), Complexo Hospitalario Universitario A Coruña (ES), Nordic Bioscience (Denmark) (DK), Instituto de Investigación Biomédica de A Coruña (ES), Imaging Center (US), Newcastle University (GB)
European Federation of Pharmaceutical Industries and Associations, European Commission
Good health and well-being
Openalex Percentile: Top 30%
Osteoarthritis Treatment and Mechanisms
DOIOpen Access PDFOpenAlex
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How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort · Osteoarthritis and Cartilage Open (2025) | TGRS Research Map | TGRS