Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels

Our findings could indicate that breast cancer patients, both those with TNBC and ER+ disease, should not consume diets high in isoflavones when treated with anti-PD1.

Institutions

Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2025-12-09
DOI
https://doi.org/10.64898/2025.12.05.692375
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels

bioRxiv (Cold Spring Harbor Laboratory)
Gut microbiota and health
article

Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels

article en

Abstract

Our findings could indicate that breast cancer patients, both those with TNBC and ER+ disease, should not consume diets high in isoflavones when treated with anti-PD1.

bioRxiv (Cold Spring Harbor Laboratory)
University of Illinois Urbana-Champaign (US), Georgetown University (US), Hormel (United States) (US), University of Minnesota System (US), Universidade Federal do Piauí (BR), Muğla University (TR)
Openalex Percentile: Top 38%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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