S1886 Increased Risk of Post-Myocardial Infarction Complications in Patients With Inflammatory Bowel Disease: A Nationwide Inpatient Sample Study From 2016 to 2022

Introduction: Inflammatory bowel disease (IBD), including both ulcerative colitis (UC) and Crohn’s disease, is associated with systemic inflammation that may predispose patients to adverse cardiovascular outcomes. However, data on post-myocardial infarction (MI) complications in this population remain limited. Methods: We conducted a retrospective cohort study using the National Inpatient Sample (NIS) database from 2016 to 2022. patients hospitalized with a primary diagnosis of acute MI were identified using International Classification of Diseases-10 -CM codes. Patients were stratified based on the presence or absence of IBD (including both UC and Crohn’s disease). Baseline characteristics, Post-MI complications, and healthcare utilization were compared between groups. Multivariate logistic regression was used to evaluate the association between IBD and post-MI complications, adjusting for demographics, comorbidities, and hospital characteristics. Results: A total of 1,456,940 patients were included, of whom 7,430 had a diagnosis of IBD. Compared to the non-IBD cohort, IBD patients were more likely to be women (37.8% vs 32.8%, P < 0.0001) and White (84.6% vs 74.3%, P < 0.0001), with lower prevalence of cardiovascular risk factors hypertension (71.9% vs 75.0%, P < 0.0001), diabetes (27.9% vs 34.8%, P < 0.0001), and hyperlipidemia (56.19% vs 63.08%, P < 0.0001). After adjustment, IBD was associated with significantly increased odds of mortality (OR 3.32, 95% CI 3.18–3.47, P < 0.0001), left ventricular rupture (OR 4.46, 95% CI 3.16–6.28, P < 0.0001), left ventricular aneurysm (OR 1.93, 95% CI 1.61–2.31, P < 0.0001), stent restenosis (OR 1.16, 95% CI 1.07–1.26, P = 0.0002), and acute mitral regurgitation (OR 9.80, 95% CI 6.81–14.10, P < 0.0001). There was no statistically significant difference in the odds of pericarditis (OR 0.84, 95% CI 0.67–1.04, P = 0.0995). Moreover, IBD patients had longer hospital stays (R = 2.13 days, 95% CI 2.03–2.23, P < 0.0001). Conclusion: Despite having a lower burden of traditional cardiovascular risk factors, patients with IBD who suffer from MI experience significantly higher rates of life-threatening cardiac complications and increased healthcare utilization. Prospective studies are warranted to better understand the underlying mechanisms and long-term impact of IBD on post-MI outcomes.