Fysiologie-gebaseerd farmacokinetisch modelleren in bijzondere patiëntenpopulaties: Inzichten in ouderen en volwassenen met obesitas

This research project aims to develop an open-source physiologically based biopharmaceutics (PBPK) model to support dose selection and improve pharmacotherapy for geriatric patients and older people. This model will integrate in vitro and in vivo data that focuses on the distinction between age and/or disease-related impact on drug absorption. Ultimately, the model could be implemented into PBB/PBPK modelling tools to predict and mechanistically inform changes in oral drug absorption in the elderly population.