The Associations Between Depression, Subjective Sleep Quality, and Health-Related Quality of Life in Patients with Meige Syndrome: A Cross-Sectional Study

Meng Li,1,* Jianhua Li,2,* Mengtian Li,1,3,* Jiaxin Li,4 Yuandong Yu,5 Kezhen Yang,1 Linghan Zhou,1 Shen Li,6 Yanhong Li,1 Qiong Li,7 Junfan Wei,2 Huawei Li1 1Nursing Department, The Third People’s Hospital of Henan Province, Zhengzhou, People’s Republic of China; 2Nursing Department, Nanjing Central Hospital, Nanjing, People’s Republic of China; 3School of Nursing, Xinxiang Medical University, Xinxiang, People’s Republic of China; 4School of Medicine, Xi’an International University, Xi’an, People’s Republic of China; 5Health Management Center, The Third People’s Hospital of Henan Province, Zhengzhou, People’s Republic of China; 6School of Rehabilitation Therapy, Henan Vocational College of Tuina, Luoyang, People’s Republic of China; 7School of Nursing, North Hennan Medical University, Xinxiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huawei Li, Nursing Department, The Third People’s Hospital of Henan Province, 198 Funiu Road, Zhengzhou, Henan, People’s Republic of China, Tel +86 13937182631, Email [email protected] Junfan Wei, Nursing Department, Nanjing Central Hospital, No. 116, Chengxian Street, Xuanwu District, Nanjing, Jiangsu, People’s Republic of China, Tel +86 13253369959, Email [email protected]: This study aimed to assess the health-related quality of life (HRQoL) in patients with Meige syndrome and to explore the associations among socio-demographic factors, depression, sleep quality, and HRQoL.Methods: A cross-sectional study was conducted using a convenience sampling method. Data were collected between March and June 2025 from six tertiary hospitals located in Henan Province and Guangdong Province. A total of 376 valid questionnaires were collected. Four instruments were used, including the socio-demographic characteristics questionnaire, the Self-Rating Depression Scale, the Pittsburgh sleep quality index, and the Short-From 36 Health Survey.Results: The current study reported a mean SF-36 score of 49.6 ± 13.2 among patients with Meige syndrome, indicating moderate HRQoL impairment. The present study identified a negative correlation between HRQoL score with depression score and sleep quality score. Multiple linear regression showed that disease duration (β = 0.17, P < 0.001), self-care ability (β = − 0.13, P = 0.013), depression (β = − 0.14, P = 0.006) and sleep quality (β = − 0.12, P = 0.021) were significant factors associated with HRQoL in Meige syndrome patients.Conclusion: Patients with Meige syndrome exhibited moderate impairment in HRQoL. Depression and poor sleep quality were significantly associated with lower HRQoL.Keywords: Meige syndrome, health-related quality of life, cross-sectional study, depression, sleep quality