Lipiden in artrose: de rol in kraakbeen homeostase en gewrichtsontsteking

Osteoarthritis (OA) is a major cause of chronic pain, disability, and socioeconomic burden worldwide. Current treatments are unable to arrest or delay disease progression. Therefore, a better understanding of the molecular mechanisms driving OA is essential to identify disease-modifying therapeutic targets. The role of lipids, a complex and diverse group of bioactive molecules, in OA pathogenesis remains largely unknown. In particular, a systematic, joint-tissue perspective on lipids is lacking, and the mechanisms underlying their dysregulation in OA remain incompletely understood. This study investigates the roles of lipids in cartilage degradation and synovial inflammation using three models, each reflecting an OA-related risk factor. Through integrated lipidomic profiling and functional analyses, we identified key lipid alterations and underlying mechanisms associated with disease development. These findings provide new insights into the molecular mechanisms of OA and highlight lipid-related processes as potential therapeutic targets.