Effects of Melatonin Disorders on Parkinson’s Disease: A Review of Mechanisms and Clinical Manifestations

Yiwei Shen,1,* Cong He,1,* Yulin Wang,1 Yu Zhang,1 Zhengnan Liu,1 Xia Chen,1 Shun Wang,1,* Yan Bai2,* 1The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Institute of Acupuncture and Moxibustion, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shun Wang, The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China, Email [email protected] Yan Bai, Institute of Acupuncture and Moxibustion, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, People’s Republic of China, Email [email protected]: Melatonin is a vital hormone that is important for antioxidant activity, neuroprotection, and biological rhythm control. Melatonin anomalies may have a high correlation with the onset and development of Parkinson’s disease, according to recent studies. A common neurodegenerative illness that severely lowers a patient’s quality of life, Parkinson’s disease is typified by non-motor symptoms and aberrant movement. A recent study found that abnormal melatonin levels may have a detrimental effect on patients’ motor function and cognitive ability, potentially exacerbating Parkinson’s disease symptoms. To completely comprehend the clinical symptoms linked to Parkinson’s disease and potential therapy options, further study is necessary to determine the exact role of melatonin in this condition. This article will investigate the relationship between melatonin and Parkinson’s disease, how it contributes to the illness’s progression, and the clinical symptoms that are linked with it in order to provide new perspectives and resources for more research and treatment strategies.Keywords: melatonin, Parkinson’s disease, mechanism, clinical manifestations, neuroprotection