Design and evolution of a synthetic small protein scaffold based on the WW domain

Funding Information: The authors would like to acknowledge the financial support of FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB, projects UIDB/04138/2020 e UIDP/04138/2020 of the Research Institute for Medicines (iMed) and Gonçalo Teixeira PhD grant (PD/BD/139800/2018; COVID/BD/152648/2022). This work has received funding from the European Union's Horizon 2020 programme under grant agreement No. 899732 (PURE Project) and from Fundação para a Ciência e Tecnologia (Portugal) and ERDF under the PT2020 Partnership Agreement (LISBOA-01-0145-FEDER-028878) for funding the Sea2See project (PTDC/BII-BIO/28878/2017) and Proteios project (PTDC/CTM-CTM/3389/2021). Publisher Copyright: © 2025 The Author(s). Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.