Forcing cell fate

The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces, long considered background players in guiding this transition, are essential regulators of chromatin accessibility and cell fate decisions.

Publication Details

Journal
UCL Discovery (University College London)
Published
2025-10-01
Primary Topic
Genomics and Chromatin Dynamics
Type
article
Field-Weighted Citation Impact
0.00
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article

Forcing cell fate

UCL Discovery (University College London)
Genomics and Chromatin Dynamics
article

Forcing cell fate

article en

Abstract

The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces, long considered background players in guiding this transition, are essential regulators of chromatin accessibility and cell fate decisions.

UCL Discovery (University College London)
Openalex Percentile: Top 38%
Genomics and Chromatin Dynamics
OpenAlex
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Forcing cell fate · UCL Discovery (University College London) (2025) | TGRS Research Map | TGRS