Гормональний статус жінок репродуктивного віку з доброякісними проліферативними захворюваннями матки

Proliferative diseases of the uterus are the most common gynecological pathology, and the frequency of combined development of hyperplastic processes of the endo- and myometrium is 63.0–73.0%. Uterine leiomyoma, adenomyosis and benign hyperplastic processes of the endometrium are manifestations of proliferative syndrome in the organs of the female reproductive system and indicate a number of common features of the pathogenetic mechanisms of their development.The objective: to study the hormonal status of reproductive age women with combined and solitary proliferative di-seases of the uterus.Materials and methods. 210 respondents of reproductive age (19–35 years) were examined, of which 30 women were almost health (Control Group) and 180 women had hyperplastic uterine processes, including 90 patients with combined proliferative uterine processes (Main Group) and 90 women with isolated proliferative uterine processes (Comparison Group). The hormonal status was assessed by determining the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), estradiol, progesterone, prolactin in the blood serum, calculating the LH/FSH index and the estradiol/progesterone ratio, taking into account data of ultrasound examination of the pelvic organs. Statistical data processing was performed using the computer program Statistica 13.3.721.Results. In the case of combined uterine pathology, the hormonal homeostasis system is subjected to significantly greater stress than in the case of solitary pathology, as evidenced by a decrease in the frequency of full menstrual cycles in almost every second woman. In women with isolated hyperplastic uterine processes, anovulatory cycles and luteal phase insufficiency occur with almost the same frequency, and in combined ones, the frequency of luteal phase insufficiency exceeds the frequency of anovulatory cycles by 1.3 times. Combined forms of the benign proliferative diseases of the uterus in reproductive age women are developed in 1.6 times more because of ovarian insufficiency than the solitary ones.Conclusions. Hormonal insufficiency was found in almost every second reproductive age women with combined hyperplastic processes of the endo- and myometrium and in every third women with solitary uterine processes. Anovulation is observed in 21.1% of patients with combined and in 15.6% with isolated forms of uterine hyperplastic processes; luteal phase insufficiency – in 26.7% and 14.4% of patients, respectively (p < 0.05).