Complete spontaneous resolution of NRAS-mosaic multiple congenital melanocytic naevi – proof of principle for therapeutic mole reversal

We present a unique case of complete spontaneous resolution of multiple congenital melanocytic naevi (CMN) with 17 years of photographic, histological and genetic evidence. This case is of biological importance as proof of principle that CMN are not permanent malformations, but rather potentially-reversable lesions. In turn, this proof of principle is of clinical importance, as the increased risk of melanoma development should have disappeared with the naevi.