a multidisciplinary, laboratory-based, modelling study

Funding Information: We would like to thank our colleagues who provided insight and expertise that greatly assisted our research: Alejandro Alfaro-Alarc\u00F3n (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Departamento de Patolog\u00EDa, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica); Stephan Hartmann (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Arne K\u00FChne (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Dominik Lehmann (Charit\u00E9 \u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Valeria Penner (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Liena de Regla Ponce Rey (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Faculty of Biology, University of Havana. Plaza de la Revoluci\u00F3n, Havana, Cuba); Nazaret Ruiz-Villalobos, Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Programa de Investigaci\u00F3n en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica). This study was supported by the EU via the project Zoonosis Emergence across Degraded and Restored Forest Ecosystems (ZOE, project number 101135094), which was awarded to JFD. Additional funding originated from the National Institutes of Health (grant U19AI181984); the Global Centers for Health and Pandemic Prevention via the German Academic Exchange Services (DAAD) project 57592642 (GLACIER) to JFD; the Berlin Institute of Health at Charit\u00E9 via a BIH-MD-Stipend to AF; a DAAD stipend to MP-O; the German Ministry of Education and Research within the framework of the project Arbofusion (project number 01DN19017A) to JFD, MMC, and EG; and the German Federal Ministry of Economic Cooperation and Development via the Deutsche Gesellschaft f\u00FCr Internationale Zusammenarbeit (project number 81262528) to JFD, EM-T, MPGM, and CACS. Work in Peru by MMC received funding from the Global Infectious Diseases Research Network at the Center for Tropical Diseases, University of Texas Medical Branch at Galveston, TX, USA. Work in Colombia by BR-O received funding from the Universidad Industrial de Santander and the Ministerio de Ciencias de Colombia (MinCiencias project numbers BPIN 2020000100126, 112189684486, and CT 629\u20132021). The Oropouche virus strain IRCCS-SCDC_1/2024 was provided by Concetta Castilletti, Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy. The Iquitos virus and Madre de Dios virus were provided by the World Reference Center for Emerging Viruses and Arboviruses through the University of Texas Medical Branch at Galveston, TX, USA. Funding Information: We would like to thank our colleagues who provided insight and expertise that greatly assisted our research: Alejandro Alfaro-Alarc\u00F3n (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Departamento de Patolog\u00EDa, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica); Stephan Hartmann (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Arne K\u00FChne (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Dominik Lehmann (Charit\u00E9 \u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Valeria Penner (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany); Liena de Regla Ponce Rey (Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Faculty of Biology, University of Havana. Plaza de la Revoluci\u00F3n, Havana, Cuba); Nazaret Ruiz-Villalobos, Charit\u00E9\u2013Universit\u00E4tsmedizin Berlin, corporate member of Freie Universit\u00E4t Berlin and Humboldt Universit\u00E4t zu Berlin, Institute of Virology, Berlin, Germany and Programa de Investigaci\u00F3n en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica). This study was supported by the EU via the project Zoonosis Emergence across Degraded and Restored Forest Ecosystems (ZOE, project number 101135094), which was awarded to JFD. Additional funding originated from the National Institutes of Health (grant U19AI181984); the Global Centers for Health and Pandemic Prevention via the German Academic Exchange Services (DAAD) project 57592642 (GLACIER) to JFD; the Berlin Institute of Health at Charit\u00E9 via a BIH-MD-Stipend to AF; a DAAD stipend to MP-O; the German Ministry of Education and Research within the framework of the project Arbofusion (project number 01DN19017A) to JFD, MMC, and EG; and the German Federal Ministry of Economic Cooperation and Development via the Deutsche Gesellschaft f\u00FCr Internationale Zusammenarbeit (project number 81262528) to JFD, EM-T, MPGM, and CACS. Work in Peru by MMC received funding from the Global Infectious Diseases Research Network at the Center for Tropical Diseases, University of Texas Medical Branch at Galveston, TX, USA. Work in Colombia by BR-O received funding from the Universidad Industrial de Santander and the Ministerio de Ciencias de Colombia (MinCiencias project numbers BPIN 2020000100126, 112189684486, and CT 629\u20132021). The Oropouche virus strain IRCCS-SCDC_1/2024 was provided by Concetta Castilletti, Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy. The Iquitos virus and Madre de Dios virus were provided by the World Reference Center for Emerging Viruses and Arboviruses through the University of Texas Medical Branch at Galveston, TX, USA. Editorial note: The Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations. Publisher Copyright: © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license