Onderzoek naar structurele evolutie en kristallisatie in supramoleculaire gels: een niet-lineaire optische studie

This PhD project presents a comprehensive investigation into FmocFF-based supramolecular gels, revealing their structural complexity, dynamic behaviour, and practical applications. Initial studies mapping FmocFF organogels in diverse solvents uncovered unexpected dynamism, a central theme is the critical role of solvent-gelator interactions in dictating gel properties. The research highlights the power of in situ characterisation, particularly Second Harmonic Generation (SHG) microscopy, which unveiled real-time structural changes and gel-to-gel transitions previously missed by ex situ techniques. This demonstrated that FmocFF gels are highly responsive to stimuli, reorganising into more thermodynamically stable configurations. Ultimately, the thesis establishes the potential of FmocFF gels as platforms for controlling crystallisation processes, exemplified by tuning gel environments to manage pharmaceutical polymorphism. Collectively, this work significantly advances the understanding of supramolecular gel systems, broadening the scope of FmocFF organogels and demonstrating their utility in controlling crystal formation.