Inhibition of Mitotic Aurora Kinase A by Alisertib Induces Apoptosis and Autophagy of Human Gastric Cancer AGS and NCI-N78 Cells [Retraction]

Yuan C, Zhou Z, Yang Y, et al. Drug Des Devel Ther. 2015;9:487–508. We, the Editors and Publisher of the journal Drug Design, Development and Therapy, have retracted the published article. After publication, concerns were raised by a third party regarding the integrity of the data in Figure 5, Figure 7 and Figure 11 of the article. Further investigations conducted by the Journal and Publisher confirmed the following: Figure 5 includes duplicate image panels between samples representative of different experimental conditions; Unexpected similarities have been identified in the Western blot data shown in Figures 5a and 7a of the above article, and Figure 4a of the authors’ published article, which represent different experimental conditions. Both articles were submitted contemporaneously: Yuan C, Zhou Z, Yang Y, et al. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells. Drug Des Devel Ther. 2015;9:1293–1318. https://doi.org/10.2147/DDDT.S74964 When approached for an explanation, the authors checked their data and confirmed there are fundamental errors present. Therefore, they have agreed to the retraction of this article. The authors apologize for this oversight. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.