Магнитные наночастицы, функционализированные аптамером, в качестве контрастного вещества для магнитно-резонансной томографии

The possibility of using superparamagnetic nanoparticles based on magnetite with a polysac- charide coating functionalized with an aptamer for in vivo tumor imaging using MRI was studied using Ehrlich ascites carcinoma as an example. The synthesized nanoparticles were studied using transmission electron microscopy, M¨ossbauer spectroscopy and ferromagnetic resonance. The synthesized nanoparti- cles were conjugated with the As42 aptamer specific to Ehrlich carcinoma cells (As42-Fe3O4-AG). The possibility of using As42-Fe3O4-AG as a contrast agent for MRI imaging of tumors in mice that formed in the lungs of animals 2 weeks after intrapulmonary administration of Ehrlich ascites carcinoma cells was shown. Aptamer AS42 specifically delivers superparamagnetic magnetite-based nanoparticles (Fe3O4- AG) that provide contrast in MRI tissue scans. The nanoparticles allow for specific recognition of solid lung tumors using MRI, which is confirmed by autopsy