Ovarian Immature Teratoma with Gliomatosis Peritonei and Nodal Gliomatosis Metastasis: A Case Report

Jiaxin Zhang,1 Hongjing Ji,1 Meiyu Sun,2 Jiahui Wang,1 Peixuan Liu,1 Lu Feng,2 Pengxin Zhang,2 Jingchun Gao1 1Department of Obstetrics & Gynecology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Department of Pathology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of ChinaCorrespondence: Jingchun Gao, Department of Obstetrics and Gynecology, First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email [email protected]: Gliomatosis peritonei (GP) is a rare condition of mature glial tissue within the peritoneum. GP has been reported in approximately 100 cases worldwide, and it rarely occurs in young women or in patients with ovarian mature or immature teratomas during childhood. In patients with ovarian immature teratoma (OIT) combined with gliomatosis peritonei, the tumor is typically large and is often detected intraoperatively. Its neuroglial component may not only spread within the peritoneum but also metastasize via the lymphatic vessels. Pathologically confirmed lymph nodes containing mature neuroglial components and positive for glial fibrillary acidic protein (GFAP) are consistent with nodal gliomatosis (NG). In this report, we present a case of gliomatosis associated with OIT combined with GP, which involves lymph nodes.Keywords: gliomatosis peritonei, ovarian immature teratoma, nodal gliomatosis, ovarian teratoma