Chronische long allograft disfunctie: van klinische voorspellers tot moleculaire pathways

Background Chronic lung allograft dysfunction (CLAD) and chronic pulmonary graft versus host disease (cGvHD) are life-threatening conditions commonly encountered after lung transplantation and allogeneic hematopoietic stem cell transplantation. Pathophysiological and molecular pathways associated with transplant-related pulmonary fibrosis leading to structural changes and lung failure in CLAD pulmonary cGvHD remain unknown. Aims The primary objective of this translational research project is to investigate the pathways and targets involved in transplant-related pulmonary fibrosis in obstructive and restrictive phenotypes of CLAD and lung cGvHD, in order to identify novel diagnostic markers and improved therapeutics, allowing to better manage rejection-mediated fibrotic lung remodeling. Methods A multi-modal approach, using human bio-samples, assessing structural organization, immunopathologic findings and transcriptome analysis of CLAD and pulmonary cGvHD. Expected results This project will gain novel, breakthrough insights in the pathophysiology of CLAD and pulmonary cGvHD, lead to novel diagnostic and better therapeutic tools, allowing for improved, personalized medical management; and result in better long-term outcomes in patients undergoing lung transplantation and allogeneic hematopoietic stem cell transplantation.