RIPK3 signaling and effects

RIPK3 is known as a necroptosis inducing cell death protein, but in recent years has been shown to exhibit alternative pathways in the central nervous system. RIPK3 can cause pro inflammatory signaling in certain cells in the brain in a necroptosis-independent pathway. This is currently being studied in our lab in the context of brain metastatic breast cancer using murine and in vitro models, with focus on the phagocytic capabilities of microglia.