Betere zorg voor chronische rhinosinusitis patiënten door het onderzoeken van nieuwe therapieën die de mucosale epitheliale barrière beïnvloeden

The current treatment options for patients suffering from chronic rhinosinusitis (CRS) are limited, hence leading to suboptimal disease control. Better understandingk of the pathophysiology and implementing of novel preventive treatment strategies is warranted. The current PhD project aims at improving the current understanding of efficacy of novel treatment optons with biologicals for CRSwNP, and to evaluate efficacy of antiviral strategies in a preventive context. Studying the effects of different biologicals on nasal epithelial barrier dysfunction, transient receptor potental expression in the (sino)nasal mucosa and systemic biomarkers, comparing the outcomes of different biologicals on clinical and immunologic features of CRS, and comparing outcomes of biological treatment with sinonasal surgery will all pave the future of CRS care. In additon, novel approaches preventing the virus-induced nasal epithelial barrier dysfunction will be studied in the context of CRS exacerbation and prevention Outcomes of this PhD transaltional research programme will have an impact on the clinical practice of patients suffering from CRS.