Cardiometabole comorbiditeiten, systemische inflammatie en lipidenveranderingen bij psoriatische artritis: relatie met uitkomsten en radiografische progressie

Psoriasis (and psoriatic arthritis are associated with several comorbidities such as type II diabetes, arterial hypertension, metabolic syndrome and coronary disease. Metabolic alterations induced by a chronic inflammatory process contribute directly to comorbidities and the latter may also affect the outcome and prognosis of the primary disease process. The objectives of this work are: - to determine the presence of clinical comorbidities in patients with psoriatic arthritis (PsA) and document disturbances in different metabolic pathways - to determine the metabolic signatures of PsA patients and their correlation with the severity of the disease - to identify baseline factors correlating with the severity of the disease and disease activity - to analyse evolution of the baseline factors and development of comorbidities over time