Utilization of a UPLC-MS/MS Approach to Elucidate the Role of ABCB1-Mediated Paclitaxel Resistance in Non-Small Cell Lung Cancer Cells

These findings reveal that the ABCB1-mediated drug efflux is a crucial mechanism underlying paclitaxel resistance in NSCLC cells, with UPLC-MS/MS serving as a sensitive analytical method to detect paclitaxel concentration. Inhibition of ABCB1 is a promising therapeutic strategy to resensitize resistant tumor cells to paclitaxel.

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Publication Details

Journal
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Published
2025-12-09
DOI
https://doi.org/10.32604/or.2025.068967
Primary Topic
Drug Transport and Resistance Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Utilization of a UPLC-MS/MS Approach to Elucidate the Role of ABCB1-Mediated Paclitaxel Resistance in Non-Small Cell Lung Cancer Cells

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
Drug Transport and Resistance Mechanisms
article

Utilization of a UPLC-MS/MS Approach to Elucidate the Role of ABCB1-Mediated Paclitaxel Resistance in Non-Small Cell Lung Cancer Cells

article en

Abstract

These findings reveal that the ABCB1-mediated drug efflux is a crucial mechanism underlying paclitaxel resistance in NSCLC cells, with UPLC-MS/MS serving as a sensitive analytical method to detect paclitaxel concentration. Inhibition of ABCB1 is a promising therapeutic strategy to resensitize resistant tumor cells to paclitaxel.

Oncology Research Featuring Preclinical and Clinical Cancer TherapeuticsVol. 34(2)
Soochow University (CN), Suzhou Municipal Hospital (CN)
Good health and well-being
Openalex Percentile: Top 33%
Drug Transport and Resistance Mechanisms
DOIOpen Access PDFOpenAlex
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Utilization of a UPLC-MS/MS Approach to Elucidate the Role of ABCB1-Mediated Paclitaxel Resistance in Non-Small Cell Lung Cancer Cells · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics (2025) | TGRS Research Map | TGRS