Coagulation Profile in Patients with Thalassemia

Background: Thalassemia is a genetic blood disorder characterized by defective hemoglobin synthesis, leading to anemia and requiring regular blood transfusions. The present study investigates coagulation profile changes in thalassemia patients and their correlation with hematological and biochemical parameters. Methods: This is hospital-based cross-sectional type of prospective study and was conducted at JLN Hospital, Ajmer, from April 2022 to April 2024. Fifty thalassemia patients and fifty healthy controls were selected. Hematological parameters, liver function tests, coagulation markers (PT, APTT, D-Dimer, Fibrinogen), and ferritin levels were assessed. Statistical analysis was performed using SPSS software. Result: The study revealed significant differences in Hb levels, liver enzymes (AST, ALT, ALP), coagulation parameters (PT, APTT), D-dimer and serum ferritin between thalassemia patients and controls. Thalassemia major patients exhibited more severe abnormalities than intermedia patients. No significant difference was observed in WBC count, Platelet count, Total Bilirubin, Albumin levels and Serum Fibrinogen. Conclusion: Thalassemia patients exhibit distinct hematological and coagulation abnormalities, with implications for clinical management and transfusion strategies. Further research is needed to explore targeted interventions to mitigate these complications.