Hyperperfusion of amygdala contributing to Takotsubo syndrome in a case of lacunar stroke: CNS scintigraphic evidences

Abstract The largely well-known causes of Takotsubo syndrome highly associated with brain disorders are seizure, infection-related encephalitis/meningitis, migraine, head injury, metastatic brain tumors, and stroke, such as brain infarction, subdural hematoma, and subarachnoid hemorrhage. Takotsubo syndrome is characterized by varying short systolic/diastolic wall-motion impairment, e.g. apical ballooning, in the left ventricle. Amygdala has also been confirmed as an indirect cause of Takotsubo syndrome. Findings of single photon emission tomography with hyperperfusion of amygdala after stroke associated with Takotsubo syndrome have not been previously reported. We herein report an unusual case of Takotsubo syndrome correlated with obvious hyperperfusion in the bilateral amygdalae due to prior stroke was assessed with brain perfusion scintigraphy is described.