Choline acetyltransferase as a marker for Merkel cells in mucosal and skin tissues

This study identified ChAT as a novel and general marker for Merkel cells in skin and oral tissues, revealing a previously unrecognized cholinergic component of Merkel cell signaling. These findings suggest a potential role of ACh in mechanotransduction and tactile sensation. By establishing ChAT as a Merkel cell marker, this study provides new insights into somatosensory biology and provides a molecular framework for exploring cholinergic mechanisms in tactile perception. These findings may inform therapeutic strategies for sensory disorders of skin and oral mucosa.