On-CellSaturation Transfer Difference NMR Spectroscopyon Ion Channels: Characterizing Negative Allosteric Modulator BindingInteractions of P2X7

Double difference STD NMR spectra for AZ10606120 and JNJ-47965567 with WT hP2X7 (Figures S1 and S2); comparison of AZ10606120 and JNJ-47965567 positions in the binding pocket from XRD of pdP2X7 (Figure S3); comparison of docking poses for AZ10606120 and JNJ-47965567 docked to WT or NAM-site mutant hP2X7 (Figures S4 and S5)

Publication Details

Journal
DIGITAL.CSIC (Spanish National Research Council (CSIC))
Published
2025-08-31
DOI
https://doi.org/10.1021/jacs.5c02985.s001
Primary Topic
Adenosine and Purinergic Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

On-CellSaturation Transfer Difference NMR Spectroscopyon Ion Channels: Characterizing Negative Allosteric Modulator BindingInteractions of P2X7

DIGITAL.CSIC (Spanish National Research Council (CSIC))
Adenosine and Purinergic Signaling
article

On-CellSaturation Transfer Difference NMR Spectroscopyon Ion Channels: Characterizing Negative Allosteric Modulator BindingInteractions of P2X7

article en

Abstract

Double difference STD NMR spectra for AZ10606120 and JNJ-47965567 with WT hP2X7 (Figures S1 and S2); comparison of AZ10606120 and JNJ-47965567 positions in the binding pocket from XRD of pdP2X7 (Figure S3); comparison of docking poses for AZ10606120 and JNJ-47965567 docked to WT or NAM-site mutant hP2X7 (Figures S4 and S5)

DIGITAL.CSIC (Spanish National Research Council (CSIC))
Openalex Percentile: Top 39%
Adenosine and Purinergic Signaling
DOIOpen Access PDFOpenAlex
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On-CellSaturation Transfer Difference NMR Spectroscopyon Ion Channels: Characterizing Negative Allosteric Modulator BindingInteractions of P2X7 · DIGITAL.CSIC (Spanish National Research Council (CSIC)) (2025) | TGRS Research Map | TGRS