TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

This repository contains the code and R scripts compiled by Kilian Dahm and Pia Grundschöttel to recreate the RNA-seq figures from the manuscript by Feiten, Dahm, and Schlepckow et al., Nature Communications, 2025 and visualize the data accordingly.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-12-02
DOI
https://doi.org/10.5281/zenodo.17793705
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Zenodo (CERN European Organization for Nuclear Research)
Neuroinflammation and Neurodegeneration Mechanisms
article

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

article en

Abstract

This repository contains the code and R scripts compiled by Kilian Dahm and Pia Grundschöttel to recreate the RNA-seq figures from the manuscript by Feiten, Dahm, and Schlepckow et al., Nature Communications, 2025 and visualize the data accordingly.

Zenodo (CERN European Organization for Nuclear Research)
German Center for Neurodegenerative Diseases (DE)
Openalex Percentile: Top 41%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism · Zenodo (CERN European Organization for Nuclear Research) (2025) | TGRS Research Map | TGRS