S1728 Prevalence and Factors Associated With Optimal Disease Control in Crohn’s Disease and Ulcerative Colitis: Views on Inflammatory Bowel Disease Expectations and Well-Being by Patients and Treatment Providers

Introduction: Views on Inflammatory Bowel Disease (IBD) Expectations and Well-being - Patients and Treatment providers (VIEW-PT): an analysis based on the IBD Disease Specific Programme (DSP)™, previously identified features of optimal disease control (ODC). This study assessed prevalence of ODC and associated factors in a real-world setting. Methods: Data were from the IBD DSP, a cross-sectional survey of healthcare professionals (HCPs) and their patients (pts) with IBD, in EU5 (France, Germany, Italy, Spain, the United Kingdom), and the United States, collected 2020-21 and 2023-24. Pts with history of moderate-to-severe IBD (Crohn’s disease or ulcerative colitis) were included in this study. HCPs reported pt demographics, clinical characteristics, treatment history, healthcare resource utilization and treatment targets set/achieved. Pts self-reported symptoms, involvement in treatment decision and health-related quality of life via Visual Analogue Scale (EQ-VAS). Pts with no key symptoms (bleeding, bowel urgency, fecal incontinence, abdominal pain, fatigue), with restored bowel movement frequency, extraintestinal manifestations control, complete mucosal healing, no steroid use, no sleep disturbance, and EQ-VAS ≥80 met criteria for ODC. Logistic regression was performed to determine association of factors with ODC. Results: Of 2614 pts with IBD, 10.0% had ODC aligned with features identified in VIEW-PT. Logistic regression analysis included 1833 pts with complete data. Pts involved in treatment decisions (Odds ratio [OR] = 4.82, P < 0.001) and who achieved set treatment targets (OR = 2.17, P = 0.002) had higher odds of achieving ODC, while pts who had not achieved set treatment targets (OR = 0.32, P = 0.002) had lower odds of achieving ODC. Other factors associated with ODC included a previous history of smoking (OR = 2.13, P = 0.004) or having never smoked (OR = 1.91, P = 0.013), having a psychological comorbidity (OR = 0.27, P = 0.002), not receiving advanced therapy (OR = 0.54, P = 0.005), and having >4 HCP visits in the past 12 months (OR = 0.42, P < 0.001). Conclusion: Pt involvement in treatment decisions and achievement of treatment targets were most strongly associated with ODC in IBD. Other significantly associated factors included no psychological comorbidities, none/ex-smoking status, and advanced therapy prescription. Involving patients in treatment decisions and setting and reaching targets may support achievement of ODC.