Pregnancy Luteoma Mimicking Ectopic Pregnancy: A Self-Resolving Lesion Undergoing Surgical Excision

Pregnancy luteoma (PL) is a rare condition, characterized by solid proliferation of luteinized cells. Most patients are asymptomatic; however, virilizing symptoms are seen in 25% of cases. They are usually detected incidentally. Here, we present a case where the patient presented with 6 weeks of amenorrhoea and acute abdominal pain with a positive urine pregnancy test. Clinically, she was diagnosed as a case of ovarian ectopic pregnancy; laparotomy and later, ovariotomy were performed. On histopathology, the lesion was diagnosed as PL. Differential diagnoses include non-neoplastic conditions like ectopic pregnancy, hyperreactio luteinalis, and ovarian neoplasms. An accurate diagnosis is important since PL is a self-resolving, non-neoplastic lesion which usually does not require surgical excision.

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Publication Details

Journal
Annals of Pathology and Laboratory Medicine
Published
2025-05-31
DOI
https://doi.org/10.21276/apalm.3498
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
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article

Pregnancy Luteoma Mimicking Ectopic Pregnancy: A Self-Resolving Lesion Undergoing Surgical Excision

Annals of Pathology and Laboratory Medicine
Ovarian cancer diagnosis and treatment
article

Pregnancy Luteoma Mimicking Ectopic Pregnancy: A Self-Resolving Lesion Undergoing Surgical Excision

article en

Abstract

Pregnancy luteoma (PL) is a rare condition, characterized by solid proliferation of luteinized cells. Most patients are asymptomatic; however, virilizing symptoms are seen in 25% of cases. They are usually detected incidentally. Here, we present a case where the patient presented with 6 weeks of amenorrhoea and acute abdominal pain with a positive urine pregnancy test. Clinically, she was diagnosed as a case of ovarian ectopic pregnancy; laparotomy and later, ovariotomy were performed. On histopathology, the lesion was diagnosed as PL. Differential diagnoses include non-neoplastic conditions like ectopic pregnancy, hyperreactio luteinalis, and ovarian neoplasms. An accurate diagnosis is important since PL is a self-resolving, non-neoplastic lesion which usually does not require surgical excision.

Annals of Pathology and Laboratory MedicineVol. 12(5)
Military Hospital (PK)
Good health and well-being
Openalex Percentile: Top 32%
Ovarian cancer diagnosis and treatment
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