Tripartite motif 13 orchestrates endoplasmic reticulum-associated degradation and endoplasmic reticulum-phagy to modulate dendritic cell-mediated immune responses in sepsis
TRIM13 acts as a key negative regulator of DC function during sepsis. Restricting TRIM13 sustains DC immunostimulatory property, counteracts sepsis-induced immunosuppression, and improves survival outcomes. These findings highlight TRIM13 as a potential therapeutic target for sepsis management.
Institutions
- Fujian Medical University (CN)
- Chinese PLA General Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-12-04
- DOI
- https://doi.org/10.1093/burnst/tkaf077
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00