Redefinindo a Avaliação do Risco Cardiovascular em Diabetes Mellitus Tipo 2: A Perspetiva SCORE2-Diabetes

Introduction: Patients with diabetes have been classified as having a high or very high cardiovascular risk. The 2021 guidelines from the European Society of Cardiology (ESC) emphasize the ongoing need for improved development of risk scores specifically tailored for evaluating cardiovascular risk in individuals with type 2 diabetes mellitus. Acknowledging this necessity, the ESC guidelines of 2023 introduced SCORE2-Diabetes, a predictive model created to assess the 10-year cardiovascular disease (CVD) risk specifically in type 2 diabetes mellitus patients. By combining traditional and diabetes-specific risk factors, this innovative tool aims to enhance risk stratification and management, providing a nuanced approach to prevent cardiovascular diseases in this high-risk population. This study aims to calculate and analyze the changes in cardiovascular risk within a cohort of patients with diabetes, utilizing the SCORE2-Diabetes. Methods: Cross-sectional, observational, descriptive and unicentric study. A cohort of patients aged 18 or older with type 2 diabetes, attending the Day Hospital, was included. Individuals on steroids or erythropoietin-stimulating agents, those undergoing dialysis, pregnant patients, and anyone who could not comply or provide informed consent were excluded. Data was collected to calculate SCORE2-Diabetes, including age, gender, age at diabetes onset, glycated hemoglobin, HDL cholesterol, total cholesterol, LDL cholesterol, creatinine, systolic blood pressure and smoking status. Descriptive and inferential analysis was performed using STATAv18 software. Results: A sample of 60 patients was considered, with 53 ultimately selected for inclusion. The median age was 68 years old (IQR 59; 75), with males constituting 58% of the sample and smokers 11%. Median glycated hemoglobin was 7% (IQR 6.5, 8.1). Utilizing the SCORE2-Diabetes for cardiovascular risk stratification, results showed 8% of patients at low risk, 32% at moderate risk, 44% at high risk, and 16% at very high risk. Notably, 40% of patients were classified as low or moderate risk, a significant finding given that previous guidelines typically categorized individuals with diabetes mellitus as high or very high risk. These downgraded patients were younger, with smaller disease duration and higher estimated glomerularfiltration rate (p <0.05). Conclusion: Our findings reveal a substantial proportion of patients previously categorized as high or very high risk now falling into the low or moderate-risk categories. The simplicity in calculation emphasizes SCORE2-Diabetes potential to refine precision in managing cardiovascular risk for this high-risk population.