Castleman's Disease of the Chest Wall Masquerading as a Breast Mass

Castleman's disease (CD) is a rare lymphoproliferative disorder with unknown etiology and is clinically associated with abnormal lymph node enlargement. CD is classified clinically as unicentric CD (UCD) or multicentric CD (MCD) and histologically as hyaline vascular variant (HVV) or plasma cell variant (PCV). Primary axillary localization of CD represents 2% of the cases. CD rarely occurs in the breasts. The CD is easily confused with lymphoma or other solid tumors. However, the infrequent occurrence of CD has led to a limited analysis of its clinical presentation and susceptibility to misdiagnosis during preliminary investigations. Therefore, accurate diagnosis requires clinical, radiological, and histopathological evaluation. We herein describe a rare case of CD in a 38-year-old female who initially presented with a swelling in the right breast. CECT as well as FNAC of the lesion was suggestive of a mesenchymal tumor. The patient underwent axillary-wide local excision.