S1486 Pattern of Joint Distribution in Peripheral Arthritis Does Not Alter Health-Related Quality of Life Across Multiple Patient-Reported Outcomes – Results From the CHASE Cohort

Introduction: Inflammatory bowel disease (IBD)-associated peripheral spondylarthritis (IBD-pSpA) is common but not well studied, with limited research regarding impact on health-related quality of life (HRQoL). The type I vs type II classification schema, which groups patient based on the distribution, number and size of involved joints, is commonly utilized in the gastroenterology literature. However, this schema is neither widely accepted within the rheumatology literature nor prospectively validated. The aim of this study was to evaluate whether the HRQoL scores vary based on the type I vs type II classification schema. Methods: We prospectively recruited patients with IBD-pSpA, defined by previously established consensus criteria via the Cohort for Healing Arthritis, Skin, and Eye Extra-Intestinal Manifestations (CHASE-EIM) from 6 sites across the United States. The relationship of clinical presentation of IBD-pSpA (number and type of involved peripheral joints) on HRQoL was assessed via 3 previously validated patient reported outcomes – the Inflammatory Bowel Disease Questionnaire (IBDQ), the Work Productivity and Activity Impairment Questionnaire (WPAI), and the Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-F). Analyses were performed using R software and a significance level of 0.05 was assumed for all tests. Results: 134 patients with IBD-pSpA (61.2% women, 70.1% with CD) were included in the analysis. 47.3% of patients had <5 joints involved and the remainder ≥5. Hands (65.7%) and knees (58.2%) were the most commonly involved joints. 103 patients completed the requested questionnaires (76.9%). There were no statistically significant differences in any of the questionnaire scores based on number of swollen or tender joints or location of swollen or tender joints (data for hands and knees reported; data for other joints not shown but no statistically significant differences identified). Conclusion: Pattern of joint involvement did not influence HRQoL across multiple previously validated PROs (IBDQ, WPAI, and FACIT-F) in patients with IBD-pSpA, casting additional doubt regarding the clinical utility of the type I vs type II classification schema in this patient population. Development of a novel PRO specific to IBD-pSpA will provide further insights into the clinical impact of IBD-pSpA and is currently underway by our group.