Decade of research on plant-based electrospun nanofiber for wound dressing: A systematic literature review (2015–2024)

The rising interest in eco-friendly wound care has driven research on electrospun nanofiber wound dressings incorporating plant- based extracts. This systematic review, following PRISMA guidelines, analyzed 50 articles published between 2015-2024 to identify research trends in materials, methods, and evaluations. Most studies emerged after 2020, with Iran, China, and India as dominant contributors. Frequently used plants include Malva sylvestris, Zataria multiflora, and Calendula officinalis, with maceration being the most common extraction technique. PVA and PCL are the primary polymers used. Characterization techniques were categorized into morphological, chemical, mechanical, and biological tests, with SEM, FTIR, tensile testing, and cytotoxicity assays being the most frequent. While many studies confirmed antimicrobial and biocompatible properties, few included in vivo or clinical validation tests. This review highlights the promising potential of combining natural bioactive compounds with nanofiber platforms and suggests the need for more advanced biological validations for clinical translation.