Exploring differential gene expression in nasal-mucus derived small extracellular vesicles: Potential biomarker for respiratory health

Introduction: Respiratory diseases, like chronic rhinosinusitis, allergic rhinitis, and asthma, pose global health concerns, affecting over 500 million people and significantly contributing to the healthcare burden. Traditional diagnostic methods often lack sensitivity and specificity, necessitating the development of novel biomarkers for early and accurate detection of specific disease conditions. Small extracellular vesicles (sEVs), nano-sized vesicles released by cells, have gained attention as carriers of molecular biomarkers due to their role in cell communication and their presence in various biological fluids. This study aims to identify respiratory-specific biomarkers within sEVs derived from nasal mucus, offering a non-invasive approach to diagnosing respiratory conditions.