Exploratory analysis of estrogen-mediated gene expression of relaxin in the hypothalamus

Introduction: Women are eight times more likely to sustain ACL injuries than men, often attributed to hormonal fluctuations. Estrogen and relaxin, a hormone influencing ligament laxity, may contribute to this disparity. Relaxin's role in altering collagen properties suggests a potential link between estrogen-regulated relaxin expression and increased injury susceptibility, particularly during the menstrual cycle's follicular phase.