Perinatal Outcomes in Pregnancies Diagnosed with Intrahepatic Cholestasis: A Retrospective Analysis Based on the Last Three Years of Data

This retrospective cohort study aimed to evaluate maternal and neonatal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP) and to compare them with matched healthy controls. A total of 70 women diagnosed with ICP and 240 controls matched for age, parity, and year were included. All participants were followed at a tertiary care center in Turkey between January 2022 and January 2025. Maternal demographics, laboratory results, obstetric characteristics, and neonatal outcomes were assessed. Subgroup analyses were conducted according to the severity of bile acid elevation and the timing of ICP diagnosis (early vs. late onset). The presence of ICP was significantly associated with increased rates of preterm delivery (35.7% vs. 5.8%, p