A self-reinforcing nanoplatform for triple-synergistic therapy: NIR-triggered photothermal/gas/chemodynamic therapy of tumors

The triple-combination therapy generated by UiO-SNO@CuS/HA was demonstrated to have much higher cancer cell killing efficacy in vitro than either single or dual therapies, and very good biocompatibility with normal cells. This study reports a rationally designed feedback-amplified nanosystem that enables potent and specific triple-synergistic tumor therapy, representing a practical strategy for advanced combinatorial cancer therapy.