Prolonged Postoperative Paralysis Following Elective Tonsillectomy: A Case of Pseudocholinesterase Deficiency

Pseudocholinesterase deficiency is a rare disorder of the enzyme butyrylcholinesterase that can lead to delayed emergence following exposure to depolarizing neuromuscular blocking agents. We report the case of a 19-year-old male who underwent elective tonsillectomy and experienced prolonged postoperative paralysis, suspected to be due to pseudocholinesterase deficiency. The patient had no significant past medical history or family history of the condition. This report highlights the clinical implications of pseudocholinesterase deficiency and discusses strategies for perioperative management.

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Publication Details

Journal
Cureus
Published
2025-12-08
DOI
https://doi.org/10.7759/cureus.98727
Primary Topic
Cholinesterase and Neurodegenerative Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Prolonged Postoperative Paralysis Following Elective Tonsillectomy: A Case of Pseudocholinesterase Deficiency

Cureus
Cholinesterase and Neurodegenerative Diseases
article

Prolonged Postoperative Paralysis Following Elective Tonsillectomy: A Case of Pseudocholinesterase Deficiency

article en

Abstract

Pseudocholinesterase deficiency is a rare disorder of the enzyme butyrylcholinesterase that can lead to delayed emergence following exposure to depolarizing neuromuscular blocking agents. We report the case of a 19-year-old male who underwent elective tonsillectomy and experienced prolonged postoperative paralysis, suspected to be due to pseudocholinesterase deficiency. The patient had no significant past medical history or family history of the condition. This report highlights the clinical implications of pseudocholinesterase deficiency and discusses strategies for perioperative management.

CureusVol. 17(12)
Rocky Vista University (US), Ascension Providence Hospital (US), Beaumont Hospital (US)
Good health and well-being
Openalex Percentile: Top 35%
Cholinesterase and Neurodegenerative Diseases
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