Central nervous system lymphoma presenting with a vitreoretinal disorder

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma. Rarely, DLBCL presents as a vitreoretinal disorder. A 60-year-old female presented with progressive visual impairment in both eyes. Extensive investigations, including three chorioretinal biopsies, failed to identify the underlying cause. Eventually, the patient developed neurological symptoms, accompanied by atypical findings on magnetic resonance imaging. Following thorough deliberation, a brain biopsy was performed, revealing DLBCL. This case underscores the diagnostic challenges associated with vitreoretinal lymphoma, even when a biopsy is performed. It highlights the necessity of a high index of suspicion and a multidisciplinary approach, emphasizing the importance of persistent diagnostic efforts to achieve an accurate diagnosis and effective treatment.