MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug Conjugates

Herein we report the development of a novel linker platform for tumour-responsive antibody-drug conjugates. A series of functionalised homo- and heterobivalent BisFab conjugates have been synthesised, comprising an MMP-cleavable peptide...

Publication Details

Journal
Apollo (University of Cambridge)
Published
2025-12-05
DOI
https://doi.org/10.17863/cam.123743
Primary Topic
HER2/EGFR in Cancer Research
Type
article
Field-Weighted Citation Impact
0.00
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article

MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug Conjugates

Apollo (University of Cambridge)
HER2/EGFR in Cancer Research
article

MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug Conjugates

article en

Abstract

Herein we report the development of a novel linker platform for tumour-responsive antibody-drug conjugates. A series of functionalised homo- and heterobivalent BisFab conjugates have been synthesised, comprising an MMP-cleavable peptide...

Apollo (University of Cambridge)
Openalex Percentile: Top 34%
HER2/EGFR in Cancer Research
DOIOpen Access PDFOpenAlex
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MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug Conjugates · Apollo (University of Cambridge) (2025) | TGRS Research Map | TGRS