Urinary Incontinence During Sleep Associated With Buspirone: A Case Report

Background: Buspirone is an anxiolytic medication that selectively alleviates anxiety without the anticonvulsant, sedative, or muscle-relaxant effects associated with benzodiazepine. To the best of our knowledge, case reports of nocturnal urinary incontinence in buspirone users have not yet been published. Case Report: We report a 52-year-old female patient with urinary incontinence during sleep (once or twice a week) associated with buspirone (10 mg/day). The patient’s nocturnal enuresis problem disappeared immediately after the discontinuation of buspirone. Conclusion: The mechanism underlying this effect is known. These medications influence neurotransmitter systems that modulate bladder control, altering micturition patterns. Antidepressants affect central nervous system pathways that regulate bladder function, potentially decreasing inhibitory control and increasing detrusor muscle sensitivity. Reporting rare drug side effects is crucial for enhancing patient safety and improving pharmacovigilance.