Non-invasive comparative study of HLA genotyping between urinary and blood DNA using sequencing-based typing and third-generation sequencing

Urinary DNA achieves blood-comparable accuracy in noninvasive HLA genotyping. Our optimized protocol overcomes DNA yield and purity limitations through dual-platform validation (SBT/TGS), establishing urine as a clinically viable alternative for HLA profiling, especially where blood sampling is unfeasible.

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Publication Details

Journal
Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
Published
2025-12-05
DOI
https://doi.org/10.1515/almed-2025-0087
Primary Topic
Renal Transplantation Outcomes and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Non-invasive comparative study of HLA genotyping between urinary and blood DNA using sequencing-based typing and third-generation sequencing

Advances in Laboratory Medicine / Avances en Medicina de Laboratorio
Renal Transplantation Outcomes and Treatments
article

Non-invasive comparative study of HLA genotyping between urinary and blood DNA using sequencing-based typing and third-generation sequencing

article en

Abstract

Urinary DNA achieves blood-comparable accuracy in noninvasive HLA genotyping. Our optimized protocol overcomes DNA yield and purity limitations through dual-platform validation (SBT/TGS), establishing urine as a clinically viable alternative for HLA profiling, especially where blood sampling is unfeasible.

Advances in Laboratory Medicine / Avances en Medicina de LaboratorioVol. 7(1)
Beijing Red Cross Blood Center (CN)
Openalex Percentile: Top 28%
Renal Transplantation Outcomes and Treatments
DOIOpen Access PDFOpenAlex
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Non-invasive comparative study of HLA genotyping between urinary and blood DNA using sequencing-based typing and third-generation sequencing · Advances in Laboratory Medicine / Avances en Medicina de Laboratorio (2025) | TGRS Research Map | TGRS