Advancing mRNA-LNP characterization: innovative chromatographic approaches for next-generation therapeutics

No single analytical technique can comprehensively characterize complex biomolecules such as mRNA-LNP products. Charlotte Barker (Editor, Vaccine Insights) speaks to Jonathan Maurer (Postdoctoral Researcher, University of Geneva) about critical quality attributes for mRNA-lipid nanoparticle formulations, novel chromatographic methods for integrity and encapsulation efficiency evaluation, and the technical challenges of characterizing large RNA therapeutics.

Publication Details

Journal
Vaccine Insights
Published
2025-10-21
DOI
https://doi.org/10.18609/vac.2025.040
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

Advancing mRNA-LNP characterization: innovative chromatographic approaches for next-generation therapeutics

Vaccine Insights
RNA Interference and Gene Delivery
article

Advancing mRNA-LNP characterization: innovative chromatographic approaches for next-generation therapeutics

article en

Abstract

No single analytical technique can comprehensively characterize complex biomolecules such as mRNA-LNP products. Charlotte Barker (Editor, Vaccine Insights) speaks to Jonathan Maurer (Postdoctoral Researcher, University of Geneva) about critical quality attributes for mRNA-lipid nanoparticle formulations, novel chromatographic methods for integrity and encapsulation efficiency evaluation, and the technical challenges of characterizing large RNA therapeutics.

Vaccine InsightsVol. 4(8)
Openalex Percentile: Top 42%
RNA Interference and Gene Delivery
DOISourceOpenAlex
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Advancing mRNA-LNP characterization: innovative chromatographic approaches for next-generation therapeutics · Vaccine Insights (2025) | TGRS Research Map | TGRS